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In the retatrutide Phase 2 trial, discontinuation due to adverse events ranged from 6% at 4 mg doses to 16% at 12 mg, compared with 0% for placebo [1]

However, once steady state is reached, both forms produce equivalent therapeutic outcomes at their respective labeled doses

Metabolic Stability More consistent drug levels could provide: Steady appetite suppression: Avoiding the "feast-famine" cycle of weekly dosing Consistent energy levels: Reduced fluctuation in metabolic rate Better glucose control: Continuous incretin effect rather than peaks and valleys Improved sleep: Less variation in nocturnal glucose and hunger hormones 3

SGLT2is have been proposed to modulate the cardiovascular system through haemodynamic effects, whereas GLP1RAs are thought to decrease adverse events through anti-atherogenic activity [3]

Pratley, MD, can be reached at [email protected]