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"Transforming obesity: The advancement of multi-receptor drugs." Cell 187.15 (2024): 3829-3853.
Therapy with GLP-1RA should therefore start with low doses that can be uptitrated ( GLP-1RA has been placed prominently in the international recommendations for the treatment of T2D as the first injectable agent before insulin due to the advantageous outcomes in cardiovascular safety studies that demonstrated a reduction of the combined cardiovascular endpoint three-component major adverse cardiovascular event (MACE-3
A meta-analysis of 26 animal studies showed that GLP-1RAs improved learning and memory in rodent models of Alzheimers disease, possibly by decreasing brain levels of A-amyloid deposition and phosphorylated tau 33
Presented for research literature review only Martins E Jr et al
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