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Tirzepatide resulted in an early trend to reduction in eGFR at 12 weeks, but this was followed by an improvement in eGFR compared with placebo with longer duration treatment, and reduction in microalbuminuria

The difference reflects population: TRIUMPH-4's osteoarthritis cohort was older and more comorbid

Seiwerth et al., 2018)

It washes away food particles that would otherwise feed cavity-causing bacteria