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For researchers tracking inflammatory markers, the reduction typically follows weight loss by a few weeks
Recent early phase clinical trials have demonstrated a higher percentage of MASH resolution in patients who were treated with GLP-1 agonists compared to placebo, although they have not yet shown a statistically significant improvement in fibrosis stage 9
Eating smaller meals, keeping fat moderate, increasing fiber, and staying hydrated can help reduce nausea, reflux, and other digestive side effects
The Retatrutide data strengthen Eli Lilly's long-term investment case
This is particularly connected to newer combined GLP-1-GIP medication tirzepatide (Zepbound), which may reduce the absorption of oral contraceptives into the system
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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