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Maintaining adequate protein intake and nutrition is important even when appetite is low

A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)

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The Future of GLP-1 Research Ongoing research is exploring new formulations, delivery methods (such as oral and implantable devices), and combination therapies

These changes can be subtle at first but are often the earliest indication that tirzepatide is starting to work