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For the non-acylated tirzepatideGLP-1Rmini-G s complex, the operations of the purification were the same as the peptide 20GLP-1RG s complex, except that the peptide was replaced by the non-acylated tirzepatide, and the detergent of SEC running buffer was changed to 0.01% digitonin
Acknowledgments: This work was supported by HCA Healthcare and/or an HCA Healthcare affiliated entity
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Safety assessments were conducted from baseline through end-of-study follow-up, and pharmacokinetic and exploratory assessments were performed at prespecified time points, including serial sampling up to 672 h after the final dose
Injection Site Reactions Injection site reactions are specific to the injectable form of semaglutide
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