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The most common side effects are mild: slight water retention, flushing, or injection site reactions
A systematic review and meta-analysis of overweight and obese patients showed modest weight loss of 510% led to reduction in LDL-C of 0.20 mmol/dL (8 mg/dL) and triglycerides by 0.13 mmol (12 mg/dL) as well as substantial reduction in blood pressure, fasting plasma glucose, and hemoglobin A1c [26]
Another hypothesis includes the normalization of autophagy, a process important in clearing up the brain from misfolded proteins, which are hypothesized to contribute to the onset and the progression of many neurodegenerative disorders
And here is something most people do not know: metformin actually increases natural GLP-1 secretion in the gut
If side effects persist, PlexusDx offers lower-dose alternatives like Microdose GLP-1 Protocol or switching to a different compound like tirzepatide, which some patients tolerate better
