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this dose also provoked the largest percentage of weight loss though the once-weekly injectable dose of semaglutide at 1 mg was similarly effective.35 Cardiovascular Protection In addition to blood glucose and weight loss benefits, GLP-1s have shown effectiveness in improving cardiovascular outcomes and reducing the risk of major cardiovascular events.36 The SELECT trial showed that semaglutide 2.4 mg weekly significantly reduced major adverse cardiovascular events, heart failure-related hospitalizations, cardiovascular deaths, and all-cause mortality in adults with overweight or obesity and established CVD, including those with and without heart failure

And it also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum

[Epub ahead of print] Posted September 22, 2016

doi: 10.3168/jds.2016-11666 27 AndersenP