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Mantej, J., Polasik, K., Piotrowska, E

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More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]

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Although, dietary Se application in aquatic animal feed is considered to have a narrow intake range for high concentration may be toxic (Nasir et al., 2015) and lack may have adverse effects on fish health, leading to tissue damage and physiological function weakening (Khan and Bano, 2016)