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doi: 10.3389/fendo.2021.645617 Received 23 December 2020 Accepted 08 March 2021 Published 25 June 2021 Volume 12 - 2021 Edited by Gaetano Santulli, Columbia University, United States Reviewed by Bo Ahrn, Lund University, Sweden

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In addition to these traditional PTMs, a structurally similar but functionally distinct class of modifications involving ubiquitin-like proteins has emerged