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Stable systematic review: PRP for musculoskeletal soft tissue injuries
Its benefits extend to supporting cardiovascular health, cognitive function, and energy production
doi:10.1056/NEJMoa2107519
Quick Takeaways Human sleep trials used 25 nmol/kg IV for 7 consecutive nights The commonly used 100250 mcg subcutaneous protocol lacks direct clinical validation DSIP demonstrates an unusually wide safety margin in animal and human research Most evidence comes from small 1980s pilot studies, not modern RCTs What DSIP Actually Is (And Why Its Misunderstood) DSIP is a nine-amino-acid neuropeptide first isolated in 1977 from the cerebral venous blood of sleeping rabbits
Tendon and ligament dose-response curves established in rats have not been bridged to humans by any published pharmacokinetic study, and no 20232026 peer-reviewed tendon or ligament trial has appeared in PubMed [6]
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