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Additionally, GLP-1 agonists significantly reduce food intake

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According to the STEP clinical trials referenced in NICE TA875, patients treated with Wegovy achieved substantial weight loss, typically in the range of 10-15% of initial body weight over 68 weeks of treatment when combined with lifestyle interventions

However, the dual action may: Intensify this effect Make it more likely to occur Make it harder for the body to compensate 4

Depending on your health history, a clinician may consider options like: Hormone therapy (HRT) : HRT is not technically a weight loss drug, but it can help you feel better by improving your sleep, mood, and joint pain, which can, in turn, help you stick with healthy habits like exercising and eating well