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doi: 10.1038/s41429-021-00463-w 166 HuangJ.HuP.YeL.ShenZ.ChenX.LiuF.et al

In contrast, this study applied stricter inclusion criteria, restricting the analysis to large randomised cardiovascular outcome trials with a minimum sample size of 3000 participants and a minimum follow-up of at least 12 months

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Less natural stimulation of the stretch receptors in your colon that trigger peristalsis, the wave-like contractions that move stool toward the exit

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