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As body weight decreases, the body's total energy expenditure declinesnot only because there is less mass to maintain, but also because metabolic rate may decrease beyond what would be predicted by weight loss alone

Available here American Journal of Clinical Nutrition: Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. October 1, 2015

At Onyx Weight Loss Clinic, we start with a smaller dose to ensure your body adjusts smoothly

Mark this date clearly on your calendar and never use tirzepatide beyond this window, as potency cannot be guaranteed

For women with ADHD, this adds another layer of complexity