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La tirzepatide entra ufficialmente in cardiologia: nello studio SUMMIT (Packer M et al., NEJM 2025), in 731 pazienti con scompenso cardiaco a frazione di eiezione preservata (HFpEF) e obesit, ha ridotto del 38% il rischio relativo di morte cardiovascolare o peggioramento dello scompenso (HR 0,62
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The Evaluate Renal Function With Semaglutide Once Weekly (FLOW) trial is the first dedicated kidney outcome study specifically designed to assess the effect of a GLP-1 receptor agonist (once-weekly subcutaneous semaglutide) in people with type 2 diabetes mellitus and CKD at high-risk of progression (Table 1, Fig
For experiment 3: fixed dose study of Atlas987 combined with paroxetine
A prespecified analysis of pooled data from the STEP-HFpEF and STEP-HFpEF DM trials demonstrated that significantly more patients treated with Wegovy 2.4 mg SC once weekly had an improvement of at least one New York Heart Association (NYHA) functional class compared to those who received placebo (32.6% versus 21.5%, respectively
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