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These effects of IGF-1 LR3 ultimately lead to a reduced insulin requirement by up to 10% in order to maintain blood sugar levels [10, 11, 12]
Itaconic acid is a bypass metabolite of the tricarboxylic acid cycle, and its accumulation in cells can regulate the body's immune activity through various pathways (157)
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The upsurge of very-low-density lipoprotein particles seems to be the core atherogenic dyslipidemia in T2DM, which is partially secondary to insulin resistance [26]
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