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Despite possessing the same type of heme in active site, PVC and HPII differ in the presence of covalent bond between tyrosine and histidine residues
On the other hand, mRNA expression of GR was reported to be downregulated in the liver of dietary MASLD rat models (Nayan et al
In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]
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