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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)

Glutathione has also been demonstrated to reduce melanin formation

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For a 5 mg vial, 2 mL of bacteriostatic water creates a 2.5 mg/mL solution

Use with caution and monitor blood pressure