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The likely explanation is the slower titration schedule

Eckel, R

Studies have found that there may be a link between the oxidative folding function of proteins in the endoplasmic reticulum and the regulatory function of Ca 2+

Evidence for Kidney Benefits Clinical trials show consistent kidney benefits: FLOW trial (semaglutide): This dedicated kidney outcome trial showed semaglutide reduced the risk of major kidney outcomes (kidney failure, significant decline in kidney function, or kidney-related death) by 24% in diabetic patients with chronic kidney disease

(21:27): So what if neurons are actually also an overlooked mechanism here, and both of these neuronal populations have the GLP-1 receptor and are accessible from the periphery, even though the child super paper in Nature doesn't mention that, but they do have the GLP-1 receptor