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The copper question is what caps it at twelve rather than letting it run indefinitely

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Oxidative stress may directly or indirectly stimulate the accumulation of extracellular matrix proteins

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J Zhejiang Univ Sci B 16:948956 Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC (2003) Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase