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Enteric nervous system The ENS is an independently functioning neural system innervating the entire GI tract and containing two bundles of ganglia: one underneath the epithelial layer of the gut (submucosal plexus) and the other between the smooth muscle layers of the gut (myenteric plexus) 25
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NICE guidance supports its use in specific patient populations where other treatments have proven inadequate
This culminated out of research led by Jens Holst (figure 26), who began his career in 1972 as a junior surgeon in the emergency ward and the department of gastric surgery at Bispebjerg Hospital in Copenhagen
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