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B12 Regulation in the Body Vitamin B12 regulation relies on drinking enough water and proper absorption to produce saliva and stomach acid

[77] Low vitamin A tends to be associated with low iron status, and the combination of vitamin A and iron is thought to reduce iron deficiencies more quickly than iron alone

Use with caution when combined with other Vitamin B12 supplements or multivitamins, as excessive doses can cause Vitamin B12 toxicity

The reality check up front: "best" here means best-studied, not proven and approved

Individuals with known B12 deficiencies, or those prone to a potential deficiency due to their lifestyle, must supplement vitamin B12