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Third, there is an additive effect on the GLP-1 concentration when metformin is added to the DPP4 inhibitor sitagliptin, suggesting a different mechanism of action of the two drugs [61]
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The plastic and rubber in syringes can sometimes interact with the peptide, and theres a higher risk of contamination and dosage inaccuracy over time
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The modified polypeptide can be combined with human albumin to enhance the resistance to DPP-4 and prolong the half-life to 5-6 days
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