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Melanotan I incorporates structural modifications that improve resistance to enzymatic breakdown
Concomitant ICV administration of GLP- 1 and GIP significantly reduced food intake, body weight, and alcohol consumption
10.1172/JCI17597 42 KristiansenM.GraversenJ
The active compound is tirzepatide, a synthetic peptide that acts as a dual agonist at both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R)
It helps transport long-chain fatty acids into the cell's mitochondria where they are burned and used as fuel
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