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This mechanism contributes to DSIPs broader effects on neuronal function and communication

The OECD 301 pass criteria are 70% DOC removal or 60% ThOD/ThCO production, and that level must be reached in a 10-day window within the 28-day test period

GPNA, L-g-glutamyl-p-nitroanilide

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Stimulation with 6-hydroxydopamine (6-OHDA) markedly downregulates nuclear factor erythroid 2related factor 2 (NRF2) expression in PC-12 cells, elevates Fe 2+ and reactive oxygen species (ROS) levels, suppresses glutathione peroxidase 4 (GPX4), promotes both ferroptosis and apoptosis, inhibits cell proliferation, and causes neuronal damage