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In 2003, for example, a multi-year study published in Neuroendocrinology Letters found that epithalamin could normalize the basic functions of the human organism, potentially extending lifespan by improving cardiovascular, endocrine, immune, and nervous function, as well as homeostasis and metabolism.2 Several publications including two systematic reviews in Advances in Gerontology have corroborated such findings.3 4 Researchers believe that epitalons therapeutic qualities may be due to the following mechanisms of action: Telomere elongation Telomeres are caps of DNA sequences at the ends of chromosomes

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As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy

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