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Dosing and Administration Typical Dose : 1.25 mg to 2 mg (0.250.4 mL) per dose Administration : Intranasal spray in one or both nostrils , as directed Timing : Use 1530 minutes before anticipated sexual activity Frequency : No more than 1 dose per 24-hour period

Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae

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These elevations can persist longer than peptide detection windows

It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation