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In previous study, L-theanine and its derivatives, ethyl 6-bromocoumarin-3-carboxylyl L-theanine (TBrC), could effectively prevent the growth and migration of highly metastatic human cervical cancer cells, which was confirmed by in vitro and in vivo studies (69)
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4.4 Combination strategies: nanomedicine-enhanced chemo-immunotherapy The most promising applications of nanomedicine in osteosarcoma immunotherapy involve combination strategies that simultaneously target multiple resistance mechanisms
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