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What may be a good way to think of that is its the Achilles heel for certain cancers: they have one gene that drives their growth
Moreover, the endogenous or exogenous risk factors that influence mucosal melanocyte transformation, as well as the identity of MM precursor lesions, are ambiguous
At this stage, VSMCs not only lose contractile phenotype but also acquire macrophage-like and inflammatory characteristics, secreting factors such as IL-1 and MMPs that exacerbate plaque instability
Radak, Z., Zhao, Z., Goto, S., & Koltai, E
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