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After being secreted into the bloodstream, GLP-1 is rapidly degraded and inactivated by dipeptidyl peptidase-4 (DPP-4), with a half-life of only 2 minutes in the body, which limits its application in glucose-lowering therapy
Kidney problems Kidney injury and worsening kidney function have been reported in some people taking GLP-1 medicines, especially in people with dehydration caused by vomiting or diarrhea
ACS Nano 18 , 3143531450 (2024)
No mutagenic or genotoxic effects have been reported
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