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Acta 1840, 847875 (2014)
Konoplev S, Jorgensen JL, Thomas DA, Lin E, Burger J, Kantarjian HM, Andreeff M , Medeiros LJ, Konopleva M
PI3K activation is involved in the translocation of GLUT4 to the plasma membrane resulting in increased glucose uptake
AML progenitor/stem cells overexpress XIAP are sensitive to the small molecular XIAP inhibitor 1396-11
Clinical Trials of topical JAK inhibitor Ruxolitinib cream met the primary endpoint in both pivotal phases 3 clinical trials with critical secondary endpoints, with a significantly higher proportion of the trial group achieving at least 75% improvement in the F-VASI score (a quantitative measure to assess skin symptoms in patients with vitiligo) relative to baseline than the placebo group at week 24 of treatment (118)
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