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The combined use of Ang-1/Tie2 agonists with other anti-inflammatory agents, such as IL-1 inhibitors, may produce synergistic effects and further enhance therapeutic outcomes
Counsel patients regarding the risk of MTC with use of Saxenda and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness)
DOI: 10.1056/NEJMoa1709038 Teva Branded Pharmaceutical Products R&D, 2021, Efficacy and Safety of 2 Dose Regimens of TEV-48125 Versus Placebo for the Preventive Treatment of Episodic Migraine
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This led to the development of exenatide and subsequent GLP-1 receptor agonists, which are now widely used to treat type 2 diabetes by enhancing insulin secretion, slowing gastric emptying, and reducing appetite
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