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But you may not notice a change to your appetite after your first dose, cautions Dr

Gastrointestinal (GI) side effects can affect absorption of contraception Both semaglutide and tirzepatide cause GI side effects like vomiting and diarrhea

GLP-1 medications essentially amplify and extend those satiety signals, making it easier to maintain a caloric deficit without the constant hunger that makes dietary restriction so difficult to sustain

Semaglutide (Wegovy) FDA-approved for: Chronic weight management Treatment of Metabolic dysfunction-Associated Steatohepatitis (MASH) approved August 2025 FDA-indicated for: Reducing risk of heart attack, stroke, and cardiovascular death in adults with established cardiovascular disease who are obese or overweight Weekly injection Clinical trials show an average weight loss of 1215% of body weight

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