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Prescribers should present compounded formulations as clinically reasonable options within a shared decision-making framework, not as guaranteed solutions

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Bone-targeted nanocarriers functionalized with moieties that bind to hydroxyapatite, the primary mineral component of bone, have been developed to overcome these barriers ( Alendronate, a bisphosphonate with high affinity for bone mineral, has been widely used for bone-targeted drug delivery

These studies typically apply the complex in a controlled injury model and score closure, tensile properties of the repaired tissue, histology and matrix composition