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Alternative targets in TED include IL-17a (blocked by the IgG1s secukinumab (Cosentyx) and vunakizumab (NCT04737330, NCT05394857)), the IL-11 receptor (NCT05331300), the IL-6 receptor (NCT05331300), and vascular endothelial growth factor (NCT04311606)
Furthermore, decreased bacterial richness has been linked to high carbohydrate 73 and high-fat/low-protein concentrations 74 , as found in the lean and Western diets, respectively, the latter result only in old-aged rats 74
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Lefebvre-Demers M, Doyon N, Fecteau S
Osteoblast stimulation
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