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In addition to the cellular changes, 7.5- and 9-month-old animals showed reduced use of hippocampus-dependent strategies, especially in the re-learning phase
Further, NICE and the BNF says that if there are neurological symptoms present, then every other day injections are the recommended treatment, so all the points you make about B12 being stored and sufficient are not really relevant
Theres no evidence that increased B12 levels are dangerous
Rare side effects may include mild pain or swelling at the injection site
The absence of receptor downregulation or tolerance development in research suggests sustained effectiveness without the need for dose escalation over time
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