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Real-time PCR analysis indicated an initial downregulation of C4 , C4A , and MBL , followed by an upregulation of CD93 , C1q , C1s , C3 , C3AR1 , C5AR1 , and C6 over time

After washing with PBS, they were incubated with the FITC-conjugated goat anti-rabbit IgG secondary antibody (1:1000)

Head-to-head context No large randomized trial has directly compared tirzepatide to liraglutide head-to-head

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The cascade of the systemic RAAS starts with the liver angiotensinogen (AGT), which is converted to Angiotensin I (ANG I) by renin, a hormone secreted by the juxtaglomerular cells