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Human Safety Data Is Minimal A tiny 2025 pilot study testing IV BPC-157 up to 20 mg in 2 healthy adults found it well tolerated with no adverse events and no biomarker changes, but 2 subjects provide essentially zero statistical power
The peptide's interaction with dopaminergic and serotonergic neurotransmitter systems extends its mechanism into the nervous system, connecting each biological action directly to a documented benefit across multiple tissue types
These include hydroxylases, transferases like Cu/Zn superoxide dismutase, cytochrome c oxidase, hephaestin, ferroxidase, ceruloplasmin, monoamine oxidase, lysyl oxidase, and dopamine -monooxygenase, which catalyzes the conversion of dopamine to epinephrine [27]
Eye Effects: Cataracts and Glaucoma There is some evidence that long-term corticosteroid use can increase the risk of cataracts and glaucoma, although this is more common with oral or injected steroids
