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Clinical trials of semaglutide (STEP programme) demonstrate that weight loss typically continues over 68-104 weeks, albeit at a slower rate after the first few months
One approach is the use of sildenafil (Watkins et al., 2000), a phosphodiesterase-5 inhibitor which mimics the effect of nitric oxide by increasing intracellular cGMP
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Bioorganic & Medicinal Chemistry, 26 (10), 27002707
These patients are candidates for oral formulations when available, but they represent fewer than 10% of the treatment population
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