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Over the last decade, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become integral in the management of T2D owing to their capacity to improve glycemic control, promote weight loss, and reduce the incidence of major adverse cardiovascular events (MACE)

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Key findings from the preclinical data: Retatrutide produced dose-dependent delayed gastric emptying Semaglutide also produced dose-dependent delayed gastric emptying The combination of retatrutide and semaglutide did not produce statistically significant differences compared to retatrutide alone In plain terms: adding semaglutide to retatrutide did nothing measurable in this specific endpoint