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It is the primary analysis reported in the NEJM paper [7]
doi: 10.1007/s00018-022-04353-8 462 YamakiH.YamaguchiM.TsuruoT.YamaguchiH
This apparently works to make the binding region similar to the original, while making the whole molecule much more stable
A lot of people do lose weight as they walk more they're eating different foods but there are people uh, and we all probably know somebody who take a trip to italy and There they don't necessarily have that same experience
This proline-rich sequence introduces conformational rigidity that strongly resists proteolytic degradation by trypsin, chymotrypsin, and catheptic proteases
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