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Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials
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The effect is dose-dependent and reversible (after discontinuation, pigmentation subsides over weeks to months)
It directly inhibits tyrosinase, the enzyme responsible for converting tyrosine into melanin, by binding to copper ions at the enzymes active site
10.1186/1471-2164-11-648 BMC Genomics 22 EzakiB.GardnerR
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