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The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects
meaning that animal studies have shown some adverse effect or there are no well-controlled studies in humans, but potential benefits may warrant use despite potential risks
J Clin Invest 1996
Topotecan alleviates acetic acid-induced ulcerative colitis in rats via attenuation of the RORT transcription factor
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