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HbA1c improvements are typically assessed at 3 months after starting treatment and following each dose escalation
The compound demonstrates pH-dependent solubility and should be reconstituted at physiological pH (6.5-7.5) for maximum stability
Consideration can be given to cautiously reinitiating JANUVIA if another etiology is deemed likely to have precipitated the acute worsening of renal function
During those four weeks, receptor desensitization and adaptation occur
Sci Rep (2018) 8(1):5276
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