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Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Figure 1 :Glutathione (GSH) chemical structural formula GSH biosynthesis is directly controlled by its synthetase, rather than as protein synthesis is conducted on the ribosome, glutathione biosynthesis includes the following two reaction, as shown in figure 2

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BPC-157 is a linear chain of fifteen residues: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Four structural features explain much of its experimental behaviour: near the N-terminus impose conformational rigidity and resist enzymatic cleavage, which accounts for its unusual stability relative to most short peptides

Choosing the right peptide, or the correct combination, requires an understanding of how they function at a cellular level 1