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Elevated alanine levels in plasma/CSF, produced from pyruvate by alanine aminotransferase, also signal MRC dysfunction, analysed via ion exchange chromatography or reverse-phase HPLC [51]
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Under normal physiological conditions, nuclear factor erythroid 2-related factor 2 (Nrf2) remains sequestered in the cytoplasm through its association with Kelch-like ECH-associated protein 1 (Keap1)
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