It is widely recognized that oxidative stress and the production of ROS have the potential to hinder mitochondrial activity 110 , leading to the suppression of STAR gene expression
If you're on Topamax but still battle intense urges to binge on your comfort foods during times of stress, grief, or when trying to cope with other difficulties in your life, know that medication alone may not be enough
For example, compounding may be necessary if a patient is allergic to a component of an FDA-approved drug and needs a special formulation without the allergen, or if a patient unable to swallow pills needs a liquid form of a drug they can drink
Rare but serious side effects include pancreatitis and kidney or gallbladder problems
Consider specialist referral if needed : If initial assessment does not identify a clear cause, your GP may refer you to an endocrinologist, NHS sexual health service, or psychosexual therapy for further evaluation