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Without Vitamin C, the collagen structure remains weak and unstable

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Fulurija A, Lutz TA, Sladko K, Osto M, Wielinga PY, Bachmann MF, et al

While flavonoids show promise as ferroptosis inhibitors for CNS diseases, especially in acute injury settings, further studies are needed to evaluate their efficacy, safety, pharmacokinetics, and blood-brain barrier penetration for clinical application

The problem is extended room-temperature storage, repeated warming, leaving the vial on a bench, or shipping and storing reconstituted solution outside a controlled cold chain