extreme fatigue semaglutide why do glp 1 cause What Should I Expect the First Week of GLP-1 can semaglutide cause extreme fatigue

Three things happen when you take semaglutide

Side Effects Comparison# Retatrutide Side Effects# Phase 2 data (n=338 obesity trial): Nausea : ~25% at higher doses (8-12 mg) Diarrhea : ~20% Vomiting : ~15% Constipation : Common Decreased appetite : Common (pharmacological effect) Heart rate : Small increase (2-4 bpm), potentially related to glucagon component Injection site reactions : Mild, transient Discontinuation rate : 6-10% due to adverse events The glucagon receptor component introduces theoretical concerns for hyperglycemia (counterbalanced by GLP-1/GIP in practice), cardiovascular effects (chronotropic glucagon action), and hepatic effects, none of which produced safety signals in Phase 2 but require larger-scale monitoring

Krayem DV, Rabiet M et al (2016b) Effect of arsenate As (V) on the biomarkers of Myriophyllum alterniflorum in oligotrophic and eutrophic conditions

To be sure, I respect that weight loss is a struggle for these patients, and I prescribe and advocate for medication to help people lose weight

Many patients struggling with weight loss on tirzepatide have not yet reached the 15 mg dose, and increasing the dose within the approved range may produce better results than adding a second medication