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There are several overlapping reasons: Food stays in the stomach longer, which can extend fullness

For people with chronic kidney disease or heart failure, SGLT2 inhibitors are often prioritised

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Other peptide hormones, such as insulin-like peptide 5 (INSL5) (44, 45), PYY (46), GIP and neurotensin (47) can be co-expressed with the GCG products depending on the topographical localization of the cell